Professor, Human Biology and Public Health Sciences Division
Endowed Chair of Graduate Studies

2003-present
Senior Staff Scientist, Human Biology, Fred Hutch
Affiliate Associate Professor, UW Department of Global Health
Faculty Consultant, Office of Education and Training, Fred Hutch
Lehman Lab
myNCBI

2021-present

2016-present
I study the evolution of human antibody responses directed against HIV-1 infection.  We sequence antibody genes from B cells within longitudinal patient blood samples to estimate how their HIV-specific antibody lineages developed.

2022-present
I study the evolution of broad neutralizing antibodies to viruses such as HIV-1 and SARS-CoV-2. More specifically, I aim to discover the antigens required to elicit their development, in view to inform vaccine design. I also have a strong interest in global public health and translating research into practical applications.

2019-present
I study mechanisms of adaptive and innate immunity against emerging and endemic human coronaviruses. 

2019-present
I am interested in applying high-throughput techniques to identify interferon-induced genes that are potent inhibitors of early viral infection and replication (restriction factors).

2020-present
I am broadly interested in host-pathogen interactions and the evolution of the immune system to target human pathogenic viruses. Specifically, understanding the natural evolution of broadly neutralizing antibodies in HIV-1 infected individuals to inform vaccine development.

2020-present
I am interested in studying mechanisms of innate and adaptive immunity to emerging viruses, including Zika virus and SARS-CoV-2.

2019-present
I am interested in studying the evolution of both neutralizing and non-neutralizing antibodies in HIV-1 infected individuals. I would also like to better understand how effector functions influence whether a given antibody will be beneficial or detrimental in the context of HIV infection.

2020-present
I am interested in the intersection of microbiology and global public health, particularly as it pertains to viruses.  I believe that understanding disease from the molecular level all the way to the population health level can help us achieve a healthier world.

2008-present
I perform Gen Probe QC HIV viral RNA loads and population based sequencing for resistant mutations for women on ARV for the QRS cohort. I’ve also been involved with neutralization assays using the PBMC and TZM methods for PBMC and 293T-passaged chimeras with monoclonal antibodies.

2019-present
I am interested in studying the diversity and evolution of HIV-1 in Kenyan infants to understand the timing of infection.

2021-present
I am interested in the relationship between infectious diseases and their hosts. Specifically, I will study how immune responses correlate with HIV clearance in Kenyan infants. 

2021-present
I am interested in studying immune responses to SARS-CoV-2; specifically, antibody responses to SARS-CoV-2 breakthrough infections in vaccinated individuals.

2022-present

2022-present

2018-present

2014-present
Co-mentored with Erick Matsen

2020-present
Co-mentored with Erick Matsen

2017-present
Co-mentored with Jesse Bloom

2020-present
Co-mentored with Erick Matsen