Research Overview

The Overbaugh lab studies the viral and immune determinants of infectious diseases, with a focus on HIV and SARS-CoV-2 infections.  We leverage natural history studies to focus our work on studying these determinants in  settings most relevant to human disease.

HIV Nab Discovery and Analysis

HIV infected infant diagram
Simonich et al. Cell Reports Medicine 2021
Diagram characterizing broadly neutralizing antibody responses
Simonich et al. Cell 2016
epitope profiling
Dingens et al., Cell Host and Microbe, 2017 Dingens et al., Immunity, 2019

ADCC Functionality of Protective MTCT Antibodies

diagram of breastfeeding hiv exposure
Yaffe and Naiman et al., Cell Reports Medicine 2021

Mutations Contributing to Nab and ADCC Function

  • How do protective Abs evolve?
  • What are the pathways of HIV and SARS-CoV-2 viral escape from protective Abs?
mutations contributing to nab and adcc function
Simonich and Doepker et al., Nature Communications 2019

Approach to Comprehensively Mapping Antibody Responses to SARS-CoV-2 and HIV

Approach to comprehensively mapping antibody responses to SARS-CoV-2 and HIV
Garrett et al., iScience 2020 Garrett et al., Cell 2021 Stoddard et al., Cell Reports 2021,

Innate immunity: Which IFN-induced genes are antiviral?

  • Inhibiting replication of transmitted HIV in primary human T cells
  • Zika virus inhibition
  • Coronavirus inhibition
IFNs are potent inhibitors of viral replication
CRISPR Screens
CRISPR screens
Gobillot et al. unpublished