Research Overview
The Overbaugh lab studies the viral and immune determinants of infectious diseases, with a focus on HIV and SARS-CoV-2 infections. We leverage natural history studies to focus our work on studying these determinants in settings most relevant to human disease.
HIV Nab discovery and analysis
Simonich et al. Cell Reports Medicine 2021
Simonich et al. Cell 2016
Dingens et al., Cell Host and Microbe, 2017
Dingens et al., Immunity, 2019
ADCC functionality of protective MTCT antibodies
Yaffe and Naiman et al., Cell Reports Medicine 2021
Mutations contributing to Nab and ADCC function
- How do protective Abs evolve?
- What are the pathways of HIV and SARS-CoV-2 viral escape from protective Abs?
Simonich and Doepker et al., Nature Communications 2019
Approach to comprehensively mapping antibody responses to SARS-CoV-2 and HIV
Garrett et al., iScience 2020
Garrett et al., Cell 2021
Stoddard et al., Cell Reports 2021,
Innate immunity: Which IFN-induced genes are antiviral?
- Inhibiting replication of transmitted HIV in primary human T cells
- Zika virus inhibition
- Coronavirus inhibition
Gobillot et al. unpublished
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© 2025 Fred Hutchinson Cancer Center, a 501(c)(3) nonprofit organization.