The Overbaugh lab studies the viral and immune determinants of infectious diseases, with a focus on HIV and SARS-CoV-2 infections. We leverage natural history studies to focus our work on studying these determinants in settings most relevant to human disease.
HIV Nab Discovery and Analysis



ADCC Functionality of Protective MTCT Antibodies

Mutations Contributing to Nab and ADCC Function
- How do protective Abs evolve?
- What are the pathways of HIV and SARS-CoV-2 viral escape from protective Abs?

Approach to Comprehensively Mapping Antibody Responses to SARS-CoV-2 and HIV

Innate immunity: Which IFN-induced genes are antiviral?
- Inhibiting replication of transmitted HIV in primary human T cells
- Zika virus inhibition
- Coronavirus inhibition


