Complete Bibliography

Visit PubMed to view Dr. Joshua Schiffer's complete publication record.

Selected Publications

HIV Cure

Reeves DB, Duke ER, Wagner TA, Palmer SE, Spivak AM, Schiffer JT. A majority of HIV persistence during antiretroviral therapy is due to infected cell proliferation. Nature Communications. 2018; 9(1):4811. PMID: 30446650, PMCID:PMC6240116.

Roychoudhury P, De Silva Feelixge H, Reeves D, Mayer BT, Stone D, Schiffer JT, Jerome KR. Viral diversity is an obligate consideration in CRISPR/Cas9 designs for targeting the HIV reservoir. BMC Biol. 2018; 16(1):75. PMID:29996827, PMCID: PMC6040082

Reeves DB, Duke ER, Hughes SM, Prlic M, Hladik F, Schiffer JT. Anti-proliferative therapy for HIV cure: a compound interest approach. Sci Rep. 2017; 7(1):4011. PMID: 28638104, PMCID: PMC5479830.

Reeves DB, Peterson CW, Kiem HP, Schiffer JT. Autologous stem cell transplantation disrupts adaptive immune responses during rebound simian/human immunodeficiency virus viremia. J Virol. 2017; 91(13) pii: e00095-17. PMID: 28404854, PMCID: PMC5469274.

Roychoudhury P, De Silva Feelixge HS, Pietz HL, Stone D, Jerome KR, Schiffer JT. Pharmacodynamics of anti-HIV gene therapy using viral vectors and targeted endonucleases. J Antimicrob Chemother. 2016; 71(8):2089-99. PMID: 27090632, PMCID: PMC4954920.

Dimitrov DT, Kiem HP, Jerome KR, Johnston C, Schiffer JT. A curative regimen would decrease HIV prevalence but not HIV incidence unless targeted to an ART-naïve population. Sci Rep. 2016; 6:22183. PMID: 26908162, PMCID: PMC4764923.

Johnston C, Harrington R, Jain R, Schiffer JT, Kiem HP, Woolfrey A. Safety and efficacy of combination antiretroviral therapy in HIV-infected adults undergoing autologous or allogeneic hematopoietic cell transplant for hematologic malignancies. Biol Blood Marrow Transplant. 2016; 22(1):149-56. PMID: 26265463, PMCID: PMC4731235.

Matrajt L, Younan PM, Kiem HP, Schiffer JT. The majority of CD4+ T-cell depletion during acute SHIV89.6P infection occurs in uninfected cells. J Virol. 2014; 88(6):3202-12. PMID: 24390339, PMCID: PMC3957925.

Schiffer JT, Swan DA, Stone D, Jerome KR. Predictors of hepatitis B cure using gene therapy to deliver DNA cleavage enzymes: a mathematical modeling approach. PLoS Comput Biol. 2013; 9(7):e1003131. PMID: 23861664, PMCID: PMC3701691.

Schiffer JT, Aubert M, Weber ND, Mintzer E, Stone D, Jerome KR. Targeted DNA mutagenesis for the cure of chronic viral infections. J Virol. 2012; 86(17):8920-36. PMID: 22718830, PMCID: PMC3416169.

Herpes Simplex Virus-2 Dynamics

Schiffer JT, Gottlieb SL. Biologic interactions between HSV-2 and HIV-1 and possible implications for HSV vaccine development. Vaccine. 2017 Sep 25. pii: S0264-410X (17)31273-2. PMID: 28958807, PMCID: PMC5867191 [Available on 2019-03-25].

Schiffer JT, Swan DA, Magaret A, Schacker TW, Wald A, Corey L. Mathematical modeling predicts that increased HSV-2 shedding in HIV-1 infected persons is due to poor immunologic control in ganglia and genital mucosa. PLoS One. 2016; 11(6):e0155124. PMID: 27285483, PMCID: PMC4902308.

Dhankani V, Kutz JN, Schiffer JT. Herpes simplex virus-2 genital tract shedding is not predictable over months or years in infected persons. PLoS Comput Biol. 2014; 10(11)e1003922. PMID: 25375183, PMCID: PMC4222642.

Schiffer JT, Mayer BT, Fong Y, Swan DA, Wald A. Herpes simplex virus-2 transmission probability estimates based on quantity of viral shedding. J R Soc Interface. 2014; 11(95):20140160. PMID: 24671939, PMCID: PMC4006256.

Schiffer JT, Wald A, Selke S, Corey L, Magaret A. The kinetics of mucosal herpes simplex virus-2 infection in humans: evidence for rapid viral-host interactions. J Infect Dis. 2011; 204(4):554-61. PMID: 21791657, PMCID: PMC3144170.

Schiffer JT, Abu-Raddad L, Mark KE, Zhu J, Selke S, Magaret A, Wald A, Corey L. Frequent release of low amounts of herpes simplex virus from neurons: results of a mathematical model. Sci Transl Med. 2009; 1(7):7ra16. PMID: 20161655, PMCID: PMC2818652.

Simulated Clinical Trials

Schiffer JT, Swan DA, Magaret A, Corey L, Wald A, Ossig J, Ruebsamen-Schaeff H, Stoelben S, Timmler B, Zimmerman H, Melhem MR, Van Wart SA, Rubino CM, Birkmann A. Mathematical modeling of herpes simplex virus-2 suppression with pritelivir predicts trial outcomes. Sci Transl Med. 2016; 8(324):324ra15. PMID: 26843190, PMCID: PMC4880060.

Schiffer JT, Swan DA, Corey L, Wald A. Rapid viral expansion and short drug half-life explain the incomplete effectiveness of current herpes simplex virus-2 directed antiviral agents. Antimicrob Agents Chemother. 2013; 57(12):5820-9. PMID: 24018260, PMCID: PMC3837890.

Schiffer JT, Magaret A, Selke S, Corey L, Wald A. Detailed analysis of mucosal herpes simplex virus-2 kinetics with and without antiviral therapy. J Antimicrob Chemother. 2011; 66(11): 2593-600. PMID: 21865349, PMCID: PMC3191945.

Tissue-Resident T Cells

Schiffer JT, Swan DA, Prlic M, Lund JM. Herpes simplex virus-2 dynamics as a probe to measure the extremely rapid and spatially localized tissue-resident T-cell response. Immunol Rev. 2018 Sep; 285(1):113-33. PMID:30129205.

Schiffer JT, Swan DA, Roychoudhury P, Lund JM, Prlic M, Zhu J, Wald A, Corey L. A fixed spatial structure of CD8+ T cells in tissue during chronic HSV-2 infection. J Immunol. 2018; 201(5):1522-35. PMID:30045971. PMCID: PMC6103892 [Available on 2019-09-01].

Schiffer JT. Mucosal HSV-2 specific CD8+ T-cells represent containment of prior viral shedding rather than a correlate of future protection. Front Immunol. 2013; 4:209. PMID: 23908652, PMCID: PMC3725545.

Schiffer JT, Swan D, Al Sallaq R, Magaret A, Johnston C, Mark KE, Selke S, Ocbamichael N, Kuntz S, Zhu J, Robinson B, Huang ML, Jerome KR, Wald A, Corey L. Rapid localized spread and immunologic containment define herpes simplex virus-2 reactivation in the human genital tract. Elife. 2013; 2:e00288. PMID: 23606943, PMCID: PMC3629793.

Schiffer JT, Abu-Raddad L, Mark KE, Zhu J, Selke S, Koelle DM, Wald A, Corey L. Mucosal host immune response predicts the severity and duration of herpes simplex virus-2 genital tract shedding episodes. Proc Natl Acad Sci USA. 2010; 107(44):18973-8. PMID: 20956313, PMCID: PMC2973882.

Viral Dynamics in Infants

Boucoiran I, Mayer BT, Krantz EM, Marchant A, Pati S, Boppana S, Wald A, Corey L, Casper C, Schiffer JT, Gantt S. Nonprimary maternal cytomegalovirus infection after viral shedding in infants. Pediatr Infect Dis J. 2018; 37(7):627-31. PMID:29889809, PMCID: PMC6016842 [Available on 2019-07-01].

Matrajt L, Gantt S, Mayer BT, Krantz EM, Orem J, Wald A, Corey L, Schiffer JT, Casper C. Virus and host-specific differences in oral human herpesvirus shedding kinetics among Ugandan women and children. Sci Rep. 2017; 7(1):13105. PMID 29026166, PMCID: PMC5638921.

Mayer BT, Krantz EM, Swan D, Ferrenberg J, Simmons K, Selke S, Huang ML, Casper C, Corey L, Wald A, Schiffer JT, Gantt S. Transient oral human cytomegalovirus infections indicate inefficient viral spread from very few initially infected cells. J Virol. 2017; 91(12). pii: e00380-17. PMID: 28381570, PMCID: PMC5446638.

Mayer BT, Matrajt L,Casper C, Krantz EM, Corey L, Wald A, Gantt S, Schiffer JT. Dynamics of persistent oral cytomegalovirus shedding during primary infection in Ugandan infants. J Infect Dis. 2016; 214(11):1735-43. PMID: 27651417, PMCID: PMC5144733.

Gantt S, Orem J, Krantz EM, Morrow RA, Selke S, Huang ML, Schiffer JT, Jerome KR, Nakaganda A, Wald A, Casper C, Corey L. Prospective characterization of the risk factors for transmission and symptoms of primary human herpesvirus infections among Ugandan infants. J Infect Dis. 2016; 214(1):36-44. PMID: 26917575, PMCID: PMC4907408.