Our Research

Research in the Campbell Lab is focused on understanding how cells communicate and interact with their surroundings. We study a family of receptors that are critical for accurate cell communication: they transverse the cell membrane and relay external signal into the cell, as well as internal signal out. These receptors must be strictly regulated: dysregulation is associated with a myriad of pathologies including autoimmune, cardiac, pulmonary and blood diseases as well as cancer and infectious diseases. Our lab utilizes a broad range of strategies in biophysics, protein engineering, biochemistry, and cell biology. Concurrently, we are developing cryo-electron microscopy (cryoEM) methods — both computational and biochemical — to enhance structural detail and characterize the dynamics of membrane protein receptors.
 

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Featured Publications

Structural and functional characterization of integrin α5-targeting antibodies for anti-angiogenic therapy

Nguyen A, Heim JB, Cordara G, Chan MC, Johannesen H, Charlesworth C, Li M, Azumaya CM, Madden B, Krengel U, Meves A, Campbell MG bioRxiv 2025 Jan 08

Evolutionary origin and structural ligand mimicry by the inserted domain of alpha-integrin proteins

 Hollis JA, Chan MC, Malik HS, Campbell MG. bioRxiv. 2023 November 05.

De novo design of highly selective miniprotein inhibitors of integrins αvβ6 and αvβ8

Roy A*, Shi L*, Chang A*, Dong X, Fernandez A, Kraft JC, Li J, Le VQ, Winegar RV, Cherf GM, Slocum D, Poulson PD, Casper GE, Vallecillo-Zuniga ML, Valdoz JC, Miranda MC, Bai H, Kipnis Y, Olshefsky A, Priya T, Carter L, Ravichandran T, Chow C, Johnson MR, Chang A, Overed-Sayer C, Finch DK, Lowe D, Bera AK, Matute-Bello G, Birkland TP, DiMaio F, Raghu G, Cochran JR, Stewart L, Campbell MG#, Van Ry PM#, Springer TA#, Baker D#. Nat Commun. 2023 Sep 13;14(1):5660.