Our Research

Research in the Campbell Lab is focused on understanding how cells communicate and interact with their surroundings. We study a family of receptors that are critical for accurate cell communication: they transverse the cell membrane and relay external signal into the cell, as well as internal signal out. These receptors must be strictly regulated: dysregulation is associated with a myriad of pathologies including autoimmune, cardiac, pulmonary and blood diseases as well as cancer and infectious diseases. Our lab utilizes a broad range of strategies in biophysics, protein engineering, biochemistry, and cell biology. Concurrently, we are developing cryo-electron microscopy (cryoEM) methods — both computational and biochemical — to enhance structural detail and characterize the dynamics of membrane protein receptors.