Xu Y, Zhang L, Liu Y, Topalidou I, Ailion M,  Zhao Z, Wang T, Chen Z, Bai J. (2021) Dopamine receptor DOP-1 engages a sleep pathway to modulate swimming in C. elegans. iScience (accepted). BioRxiv [Preprint] February 18, 2021. Available from:

Li L, Liu H, Krout M, Richmond J, Wang Y, Bai J., Weeratunga S, Collins BM, Donovan V, Yu Y, Xia J, Tang J, Liu J, and Hu Z. (2021) A novel dual Ca2+ sensor system regulates Ca2+-dependent neurotransmitter release in C. elegans. Journal of Cell Biology 220(4): e202008121. PMCID: PMC7883739.

Rabinowitch I, Upadhyaya B, Pant A, Galski D, Kreins Y, Bai J. (2021) Circumventing neural damage in a C. elegans chemosensory circuit using genetically engineered synapses. Cell Systems (in press), Jan 13, (20) 30504.

2020 - 2016 

Voelker L, Upadhyaya B, Ferkey DM, Woldemariam S, L’Etoile ND, Rabinowitch I, Bai J (2019) INX-18 and INX-19 play distinct roles in electrical synapses that modulate aversive behavior in Caenorhabditis elegans. PLoS Genetics, 15(10):e1008341. PMCID: PMC6837551.

Kurshan PT, Merrill SA, Dong Y, Ding C, Hammarlund M, Bai J, Jorgensen EM, and Shen K (2018) γ-Neurexin and Frizzled mediate parallel synaptogenic pathways antagonized by receptor endocytosis. Neuron. 100(1) 150-166. PMID: 30269993.

Chew YL, Tanizawa Y, Cho, Y, Zhao B, Yu AJ, Ardiel EL, Rabinowitch I, Bai J, Rankin CH, Lu H, Beets I, and Schafer WR (2018) An Afferent Neuropeptide System Transmits Mechanosensory Signals Triggering Sensitization and Arousal in C. elegans. Neuron. 99(6) 1233-1246. PMCID: PMC6162336.

Poudel K, Roh-Johnson M, Su A, Ho T, Mathsyaraja H, Anderson S, Grady WM, Moens C, Conacci-Sorrell M, Eisenman RN, and Bai J. (2018) Competition between TIAM1 and membranes balances Endophilin A3 activity in cancer metastasis. Dev Cell. 45:738-752. PMCID: PMC6095642.

Thapliyal S, Vasudevan A, Dong Y, Bai J, Koushika SP, and Babu K. (2018) The C-terminal of CASY-1/Calsyntenin regulates GABAergic synaptic transmission at the Caenorhabditis elegans neuromuscular junction, PLoS Genetics, 14(3):e1007263. doi: 10.1371/journal.pgen.1007263. PMCID: PMC5864096

Han B, Dong Y, Zhang L, Liu Y, Rabinowitch I, Bai J (2017) Dopamine signaling tunes spatial pattern selectivity in C. elegans. eLife. 6 PMCID: PMC5370180.

Rabinowitch I, Treinin M, Bai J. (2016) Artificial Optogenetic TRN Stimulation of C. elegans. Bio Protoc. 6(20); e1966. doi: 10.21769/BioProtoc. 1966. PMCID: PMC5697792.

Anderson S, Poudel K, Roh-Johnson M, Brabletz T, Yu M, Grady WM, Bai J, Moens CB, Eisenman RN, Conacci-Sorrell M (2016) MYC-nick promotes cell migration by inducing fascin expression and Cdc42 activation. PNAS, 37, E5481–E5490. doi: 10.1073/pnas.1610994113. PMCID: PMC5027433

Poudel K, Dong Y, Yu H, Su A, Ho T, Liu Y, Schulten K, & Bai J (2016) A Time-Course of Orchestrated Endophilin Action in Sensing, Bending, and Stabilizing Curved Membranes. Mol. Biol. Cell, 27, 2119-2132.

Rabinowitch I, Laurent P, Zhao B, Beets I, Schoofs L, Bai J, Schafer W, and Treinin M (2016) Neuropeptide-Driven Cross-Modal Plasticity Following Sensory Loss in C. elegans. PLoS Biol. 14(1):e1002348. doi: 10.1371/journal.pbio.1002348.

Rabinowitch I, Bai J. (2016) The foundation of cross-modal plasticity. Commun Integr Biol. 9, PMCID: PMC4857785. [Invited Commentary]

2015 - 2011

Dong Y, Gou Y, Li Y, Liu Y, Bai J. (2015) Synaptojanin cooperates in vivo with endophilin through an unexpected mechanism. eLife. 4.

Chang CW, Hui E, Bai J, Bruns D, Chapman ER, Jackson MB. (2015) A structural role for the synaptobrevin 2 transmembrane domain in dense-core vesicle fusion pores. J Neurosci. 35: 5772-5780.

Wragg RT, Gouzer G, Bai J, Arianna G, Ryan TA, Dittman JS. (2015) Synaptic activity regulates the abundance and binding of complexin. Biophys J. 1318-1329.

Poudel, K.R. and Bai, J. (2014) Synaptic vesicle morphology: a case of protein sorting? Curr Opin Cell Biol. 26C: 28-33. [Invited Review]

Radoff, D.T., Dong, Y., Snead, D., Bai, J., Eliezer, D., & Dittman, J.S. (2014). The accessory helix of complexin functions by stabilizing central helix secondary structure. eLife 3.

Wragg RT, Snead D*, Dong Y*, Ramlall TF, Menon I, Bai J, Eliezer D, and Dittman JS. (2013) Synaptic vesicles position complexin to block spontaneous fusion. Neuron 77, 323-334.

Thompson-Peer*, K.L., Bai, J.*, Hu, Z. & Kaplan, J.M. (2012, * Co-first authors). HBL-1 patterns synaptic remodeling in C. elegans. Neuron 73(3): 453-465.

2010 - 2006

Bai, J., Hu, Z., Dittman, J.S., Pym, E.C. & Kaplan, J.M. (2010). Endophilin functions as a membrane-bending molecule and is delivered to endocytic zones by exocytosis. Cell 143(3): 430-441.

Vashlishan, A.B., Madison, J.M., Dybbs, M., Bai, J., Sieburth, D., Ch'ng, Q., Tavazoie, M. & Kaplan, J.M. (2008). An RNAi screen identifies genes that regulate GABA synapses. Neuron 58(3): 346-361.

Wang, C.T., Bai, J., Chang, P.Y., Chapman, E.R. & Jackson, M.B. (2006). Synaptotagmin-Ca2+ triggers two sequential steps in regulated exocytosis in rat PC12 cells: fusion pore opening and fusion pore dilation. Journal of Physiology 570(2): 295-307.

Liu, W., Montana, V., Bai, J., Chapman, E.R., Mohideen, U. & Parpura, V. (2006). Single molecule mechanical probing of the SNARE protein interactions. Biophysical Journal 91(2): 744-758.

Li, S.*, Bai, J.*, Park, Y.D. & Zhou, H.M. (2006, * Co-first authors). Capture of monomeric refolding intermediate of human muscle creatine kinase. Protein Science 15(1): 171-181.

Hui, E., Bai, J. & Chapman, E.R. (2006). Ca2+-triggered simultaneous membrane penetration of the tandem C2-domains of synaptotagmin I. Biophysical Journal 91(5): 1767-1777.

2005 - 2001

Richards, D.A., Bai, J. & Chapman, E.R. (2005). Two modes of exocytosis at hippocampal synapses revealed by rate of FM1-43 efflux from individual vesicles. Journal of Cell Biology 168(6): 929-939.

Maher, B.J., Mackinnon, R.L., Bai, J., Chapman, E.R. & Kelly, P.T. (2005). Activation of postsynaptic Ca2+ stores modulates glutamate receptor cycling in hippocampal neurons. Journal of Neurophysiology 93(1): 178-188.

Madziva, M.T., Bai, J., Bhalla, A., Chapman, E.R. & Edwardson, J.M. (2005). Effects of synaptotagmin reveal two distinct mechanisms of agonist-stimulated internalization of the M4 muscarinic acetylcholine receptor. British Journal of Pharmacology 144(6): 761-771.

Hui, E., Bai, J., Wang, P., Sugimori, M., Llinas, R.R. & Chapman, E.R. (2005). Three distinct kinetic groupings of the synaptotagmin family: candidate sensors for rapid and delayed exocytosis. PNAS 102(14): 5210-5214.

Han, X., Wang, C.T., Bai, J., Chapman, E.R. & Jackson, M.B. (2004). Transmembrane segments of syntaxin line the fusion pore of Ca2+-triggered exocytosis. Science 304(5668): 289-292.

Bai, J., Wang, C.T., Richards, D.A., Jackson, M.B. & Chapman, E.R. (2004). Fusion pore dynamics are regulated by synaptotagmin*t-SNARE interactions. Neuron 41(6): 929-942.

Bai, J., Tucker, W.C. & Chapman, E.R. (2004). PIP2 increases the speed of response of synaptotagmin and steers its membrane-penetration activity toward the plasma membrane. Nature Structural & Molecular Biology 11(1): 36-44.

Bai, J. & Chapman, E.R. (2004). The C2 domains of synaptotagmin-partners in exocytosis. Trends in Biochemical Sciences 29(3): 143-151.

Wu, Y., He, Y., Bai, J., Ji, S.R., Tucker, W.C., Chapman, E.R. & Sui, S.F. (2003). Visualization of synaptotagmin I oligomers assembled onto lipid monolayers. PNAS 100(4): 2082-2087.

Wang, P., Wang, C.T., Bai, J., Jackson, M.B. & Chapman, E.R. (2003). Mutations in the effector binding loops in the C2A and C2B domains of synaptotagmin I disrupt exocytosis in a nonadditive manner. Journal of Biological Chemistry 278(47): 47030-47037.

Wang, C.T., Lu, J.C., Bai, J., Chang, P.Y., Martin, T.F., Chapman, E.R. & Jackson, M.B. (2003). Different domains of synaptotagmin control the choice between kiss-and-run and full fusion. Nature 424(6951): 943-947.

Tucker, W.C., Edwardson, J.M., Bai, J., Kim, H.J., Martin, T.F. & Chapman, E.R. (2003). Identification of synaptotagmin effectors via acute inhibition of secretion from cracked PC12 cells. Journal of Cell Biology 162(2): 199-209.

Tanaka, J., Yan, Y., Choi, J., Bai, J., Klenchin, V.A., Rayment, I. & Marriott, G. (2003). Biomolecular mimicry in the actin cytoskeleton: mechanisms underlying the cytotoxicity of kabiramide C and related macrolides. PNAS 100(24): 13851-13856.

Edwardson, J.M., Wang, C.T., Gong, B., Wyttenbach, A., Bai, J., Jackson, M.B., Chapman, E.R. & Morton, A.J. (2003). Expression of mutant huntingtin blocks exocytosis in PC12 cells by depletion of complexin II. Journal of Biological Chemistry 278(33): 30849-30853.

Bai, J. & Chapman, E.R. (2003). Application of fluorescent probes to study mechanics and dynamics of Ca2+-triggered synaptotagmin C2 domain-membrane interactions. Methods in Enzymology 360: 238-258.

Bai, J.*, Wang, P*. & Chapman, E.R. (2002, * Co-first authors). C2A activates a cryptic Ca2+-triggered membrane penetration activity within the C2B domain of synaptotagmin I. PNAS 99(3): 1665-1670.

Littleton, J.T., Bai, J., Vyas, B., Desai, R., Baltus, A.E., Garment, M.B., Carlson, S.D., Ganetzky, B. & Chapman, E.R. (2001). Synaptotagmin mutants reveal essential functions for the C2B domain in Ca2+-triggered fusion and recycling of synaptic vesicles in vivo. Journal of Neuroscience 21(5): 1421-1433.

Li, S., Bai, J., Park, Y.D. & Zhou, H.M. (2001). Aggregation of creatine kinase during refolding and chaperonin-mediated folding of creatine kinase. International Journal of Biochemistry & Cell Biology 33(3): 279-286.

Earles, C.A.*, Bai, J.*, Wang, P. & Chapman, E.R. (2001, * Co-first authors). The tandem C2 domains of synaptotagmin contain redundant Ca2+ binding sites that cooperate to engage t-SNAREs and trigger exocytosis. Journal of Cell Biology 154(6): 1117-1123.

Li S, Bai J, Park YD, Zhou HM. (2001) Aggregation of creatine kinase during refolding and chaperonin-mediated folding of creatine kinase. Int J Biochem Cell Biol. 279-286.

2000 - 1996

Bai, J., Earles, C.A., Lewis, J.L. & Chapman, E.R. (2000). Membrane-embedded synaptotagmin penetrates cis or trans target membranes and clusters via a novel mechanism. Journal of Biological Chemistry 275(33): 25427-25435.

Davis, A.F., Bai, J., Fasshauer, D., Wolowick, M.J., Lewis, J.L. & Chapman, E.R. (1999). Kinetics of synaptotagmin responses to Ca2+ and assembly with the core SNARE complex onto membranes. Neuron 24(2): 363-376.

Wang HJ, Bai J, Liu DS, Zhang T, Zhou HM. (1999) Preparation and properties of immobilized pig kidney aminoacylase and optical resolution of N-acyl-DL-alanine. Appl Biochem Biotechnol. 183-191.

Bai, J., Xu, D., Wang, H.R., Zheng, S.Y. & Zhou, H.M. (1999). Evidence for the existence of an unfolding intermediate state for aminoacylase during denaturation in guanidine solutions. Biochimica et Biophysica Acta 1430(1): 39-45.

Luo W, Xie WZ, Bai J, Zhou HM. (1998) Kinetics of slow reversible inhibition of human muscle creatine kinase by planar anions. J Biochem. 702-706.

Bai J, Zheng SY, Zhou HM. (1998) Inactivation of creatine kinase is due to the conformational changes of the active sites during thermal denaturation. Biochem Mol Biol Int. 941-951.

Bai J, Wang HJ, Zhou HM. (1998) Alkaline-induced unfolding and salt-induced folding of pig heart lactate dehydrogenase under high pH conditions. Int J Biol Macromol. 127-133.

Bai J, Wang HJ, Liu DS, Zhou HM. (1997) Kinetics of thermal inactivation of lactate dehydrogenase from rabbit muscle. J Protein Chem. 801-807.

He B, Bai J, Zhou HM. (1997) Comparison of inactivation and unfolding of yeast alcohol dehydrogenase during thermal denaturation. Int J Biochem Cell Biol. 1997 Jul;29(7):1021-1028.

Wang HR, Bai J, Zheng SY, Wang ZX, Zhou HM. (1996) Ascertaining the number of essential thiol groups for the folding of creatine kinase. Biochem Biophys Res Commun. 174-180.