Caleigh earned degrees in Chemistry and Biology from the University of Virginia before starting her graduate work in the lab of Dr. Teru Nakagawa at Vanderbilt University. There, she used cryo-EM to determine the structures of TRPC3, TRPC6, and IP3R ion channels and became interested in using the technique to address biophysical questions about integral membrane proteins. During a postdoc at UCSF in Yifan Cheng's lab, Caleigh collaborated with Christian Billesbøelle, in the Manglik lab, to determine structures of ferroportin to better understand the function of the human body's only iron exporter and how it can be manipulated by small molecules. She is interested in cryo-EM technology development and characterization of both hardware and software tools. Now she is the Associate Director of the Electron Microscopy Shared Resource at Fred Hutch.