Fred Hutch's Structural Biology and Molecular Biophysics Journal Club is held from 11:00 am - 12:00 pm on Thursdays on the Microsoft Teams channel "Structural Biology Journal Club". Email Lindsey at firstname.lastname@example.org for an invite.
|Date||Presenter||Topic / Manuscript|
|October 29||Barry Stoddard||Teremoto et al. and Hall (2020) “Pentratricopeptide repeats of protein-only RNAse P use a distinct mode to recognize conserved bases and structural elements of pre-tRNA” Nucleic Acids Research doi: 10.1093/nar/gkaa627.
|November 12||Julian Simon||
Pan et al. (2020) "An orally available non-nucleotide STING anatogonist with anti-tumor activity" Science 369 (935)
|November 19||Melody Campbell||"Cryo-EM structure of the SARS-CoV-2 3a ion channel in lipid nanodiscs" David M. Kern, Ben Sorum, Christopher M. Hoel, Savitha Sridharan, Jonathan P. Remis, Daniel B. Toso, Stephen G. Brohawn. bioRxiv 2020.06.17.156554. DOI|
|December 10||Phil Bradley||Discussion of Google's DeepMind AI (https://www.nature.com/articles/d41586-020-03348-4)|
|January 7||Roland Strong||Wrobel et al. (2020) “SARS-CoV-2 and bat RaTG13 spike glycoprotein structures inform on virus evolution and furin-cleavage effects” Nature Structural & Molecular Biology 27: 763 - 767. DOI|
|January 21||Betty Shen (Stoddard Lab)||
Coordination of phage genome degradation versus host genome protection by a bifunctional restriction-modification enzyme revealed by cryoEM.
Punjani, A., Zhang, H. & Fleet, D.J. Non-uniform refinement: adaptive regularization improves single-particle cryo-EM reconstruction. Nat Methods 17, 1214–1221 (2020). DOI
Punjani, A. & Fleet, D.J. 3D Variability Analysis: Resolving continuous flexibility and discrete heterogeneity from single particle cryo-EM. bioRxiv 2020.04.08.032466. DOI
|February 4||Lindsey Doyle (Stoddard Lab)||P.-A. Koenig et al., "Structure-guided multivalent nanobodies block SARS-CoV-2 infection and suppress mutational escape" Science 10.1126/science.abe6230 (2021). DOI|
||Safia Aljedani (Pancera Lab)||Pholcharee, T., Oyen, D., Flores-Garcia, Y. et al. Structural and biophysical correlation of anti-NANP antibodies with in vivo protection against P. falciparum. Nat Commun 12, 1063 (2021). DOI|
|March 4||Nick Hurlburt (Pancera Lab)|
|March 18||Peter Rupert (Strong Lab)|
|April 1||Rachel Werther (Campbell Lab)|
|April 15||Caleigh Azuyama (Manager, Fred Hutch CryoEM facilty and Staff Scientist)|
|April 29||Justus Rodarte (Pancera Lab)|
|May 13||Madison Kennedy (Stoddard Lab/UW)
|May 27||Abigail Lambert (Stoddard Lab)|
|June 10||Juliana Young (Stoddard Lab)|
|June 24||Marie Pancera|