Journal Club
2021-2022 FHCRC Structural Biology and Molecular Biophysics Journal Club
Fred Hutch's Structural Biology and Molecular Biophysics Journal Club is held from 11:00 am - 12:00 pm on Thursdays.
| Date | Presenter | Topic / Manuscript |
|---|---|---|
| September 29 | Dr. Barry Stoddard | "Structural and mechanistic studies of a bifunctional homing endonuclease and intron maturation factor, I-AniI” Suggested Reading: Liu, D. et al. (2022) “Sub-3-Å cryo-EM structure of RNA enabled by engineered homomeric self-assembly” Nature Methods 19: 576 - 585 (PubMed 35501384) https://www.nature.com/articles/s41592-022-01455-w |
| October 20 | Dr. Melody Campbell | Melody will present some of her research |
| November 10 | Nick Hurbert (Pancera Group) | "The structure of human B cell receptors" Suggested Readings: Ma X, Zhu Y, Dong D, Chen Y, Wang S, Yang D, Ma Z, Zhang A, Zhang F, Guo C, Huang Z. Cryo-EM structures of two human B cell receptor isotypes. Science. 2022 Aug 19;377(6608):880-885. doi: 10.1126/science.abo3828. Epub 2022 Aug 18. PMID: 35981028. Su Q, Chen M, Shi Y, Zhang X, Huang G, Huang B, Liu D, Liu Z, Shi Y. Cryo-EM structure of the human IgM B cell receptor. Science. 2022 Aug 19;377(6608):875-880. doi: 10.1126/science.abo3923. Epub 2022 Aug 18. PMID: 35981043. |
| December 1 | Peter Rupert (Strong Group) | "Mesothelin: antibody development structural studies" |
| December 15 | Jeremy Hollis (Campbell Group) | "The Structural Basis of Gamete Interactions" Suggested Reading: Ohto U, Ishida H, Krayukhina E, Uchiyama S, Inoue N, Shimizu T. Structure of IZUMO1-JUNO reveals sperm-oocyte recognition during mammalian fertilization. Nature. 2016 Jun 23;534(7608):566-9. doi: 10.1038/nature18596. Epub 2016 Jun 15. PMID: 27309808. Aydin H, Sultana A, Li S, Thavalingam A, Lee JE. Molecular architecture of the human sperm IZUMO1 and egg JUNO fertilization complex. Nature. 2016 Jun 23;534(7608):562-5. doi: 10.1038/nature18595. Epub 2016 Jun 15. PMID: 27309818; PMCID: PMC5319863. |
| January 5 | Adam Nguyen (Campbell Group) | "Utilizing hydrogen-deuterium exchange coupled with mass spectrometry as a complementary tool for cryoEM and structural biology" Suggested readings: Fagnen et al. (2020) "New Structural insights into Kir channel gating from molecular simulations, HDX-MS and functional studies" Sci Reports 10: 8329. Fernandes et al. (2022) "Cryo-electron microscopy unveils unique structural features of the human Kir2.1 channel" Science Advances 8 (38). |
| January 26 | Ulysses Foote (Strong Group) | R.J. Borges, F.F. Cardoso, C. de Carvalho et al., Structural and functional studies of a snake venom phospholipase A2-like protein complexed to an inhibitor from Tabernaemontana catharinensis, Biochimie, https://doi.org/10.1016/j.biochi.2022.10.011 |
| February 16 | Thamiya Vasanthakumar (Campbell Group) | Wang et al. (2023) “Structural basis of V-ATPase Vo region assembly by Vmal2p, 21p and 22p” Proc. Nat. Acad. Sci. (advance access) https://doi.org/10.1073/pnas.2217181120 |
| March 9 | Gargi Kher (Pancera Group) | Vaney, MC., Dellarole, M., Duquerroy, S. et al. "Evolution and activation mechanism of the flavivirus class II membrane-fusion machinery." Nat Commun 13, 3718 (2022). DOI |
| March 30 | Madison Kennedy (Stoddard Group) | Lurie C.L. et al. and Ohi, M.D. (2020) “Structural analysis of the Legionella pneumophila Dot/Icm type IV secretion system core complex” eLife. DOI |
| April 20 | Andres Fernandez (Campbell Group) | |
| May 11 | Juliana Young (Stoddard / McGuire Groups) | |
| June 1 | Matthew Chan (Campbell Group) | |
| June 22 | Morgan McGovern (Pancera Group) |
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