Journal Club

Crystals of a computationally designed protein
Crystals of a computationally designed protein Image by Lindsey Doyle

2020-2021 FHCRC Structural Biology and Molecular Biophysics Journal Club

Fred Hutch's Structural Biology and Molecular Biophysics Journal Club is held from 11:00 am - 12:00 pm on Thursdays on the Microsoft Teams channel "Structural Biology Journal Club". Email Lindsey at for an invite.

Date Presenter Topic / Manuscript
October 29 Barry Stoddard Teremoto et al. and Hall (2020) “Pentratricopeptide repeats of protein-only RNAse P use a distinct mode to recognize conserved bases and structural elements of pre-tRNA” Nucleic Acids Research doi: 10.1093/nar/gkaa627. 
November 12 Julian Simon

Pan et al. (2020) "An orally available non-nucleotide STING anatogonist with anti-tumor activity" Science 369 (935)

November 19 Melody Campbell "Cryo-EM structure of the SARS-CoV-2 3a ion channel in lipid nanodiscs" David M. Kern, Ben Sorum, Christopher M. Hoel, Savitha Sridharan, Jonathan P. Remis, Daniel B. Toso, Stephen G. Brohawn. bioRxiv 2020.06.17.156554. DOI
December 10 Phil Bradley Discussion of Google's DeepMind AI (
January 7 Roland Strong Wrobel et al. (2020) “SARS-CoV-2 and bat RaTG13 spike glycoprotein structures inform on virus evolution and furin-cleavage effects” Nature Structural & Molecular Biology 27: 763 - 767. DOI
January 21 Betty Shen (Stoddard Lab)

Coordination of phage genome degradation versus host genome protection by a bifunctional restriction-modification enzyme revealed by cryoEM.

Punjani, A., Zhang, H. & Fleet, D.J. Non-uniform refinement: adaptive regularization improves single-particle cryo-EM reconstruction. Nat Methods 17, 1214–1221 (2020). DOI

Punjani, A. & Fleet, D.J. 3D Variability Analysis: Resolving continuous flexibility and discrete heterogeneity from single particle cryo-EM. bioRxiv 2020.04.08.032466. DOI

February 4 Lindsey Doyle (Stoddard Lab) P.-A. Koenig et al., "Structure-guided multivalent nanobodies block SARS-CoV-2 infection and suppress mutational escape" Science 10.1126/science.abe6230 (2021). DOI
February 18
Safia Aljedani (Pancera Lab) Pholcharee, T., Oyen, D., Flores-Garcia, Y. et al. Structural and biophysical correlation of anti-NANP antibodies with in vivo protection against P. falciparumNat Commun 12, 1063 (2021). DOI
March 4 Nick Hurlburt (Pancera Lab)  
March 18 Peter Rupert (Strong Lab)  
April 1 Rachel Werther (Campbell Lab)  
April 15 Caleigh Azuyama (Manager, Fred Hutch CryoEM facilty and Staff Scientist)  
April 29 Justus Rodarte (Pancera Lab)  
May 13 Madison Kennedy (Stoddard Lab/UW)
May 27 Abigail Lambert (Stoddard Lab)  
June 10 Juliana Young (Stoddard Lab)  
June 24 Marie Pancera