Journal Club

Crystals of a computationally designed protein
Crystals of a computationally designed protein Image by Lindsey Doyle

2024-2025 FHCRC Structural Biology and Molecular Biophysics Journal Club

Fred Hutch's Structural Biology and Molecular Biophysics Journal Club is held 10:30 am - 11:30 am on Thursdays in B1-072/074 unless otherwise noted on the dates below.

DatePresenterTopic / Manuscript
October 3 (D1-080/084 - Sze)Barry StoddardKojima, KK and Kobayashi, I. (2023) “Base-excision restriction enzymes: expanding the world of epigenetic immune systems” DNA research 30: 1 - 15. DOI
October 24 (M4-A805/A817)Adam Nguyen (Campbell Lab)

"cryoEM Structures of tyrosine kinase receptors"

Reading: Huang et al. and Kuriyan, J. (2021) "A molecular mechanism for the generation of ligand-dependent differential outputs by the epidermal growth factor receptor" eLife  (https://doi.org/10.7554/eLife.73218)

November 14 (D1-080/084 - Sze)Peter Rupert (Strong Lab)

“Ferritin-scFv: A potential method for mapping of epitopes”

Reading: Knovich et al. (2009) "Ferritin for the Clinician" Blood Reviews 23: 95 -104. https://www.sciencedirect.com/science/article/pii/S0268960X08000660

December 19 (S1-141/142 - Steamplant)Juliana Young (Stoddard Lab)

“The mobilization, divergence, degradation, and reconstruction of modern-day and ancestral homing endonucleases”

January 9 (B1-072/074)
Derin Kara (Pancera Lab)

"Computational design of prefusion-stabilized Herpesvirus gB trimers”

Reading:   https://pmc.ncbi.nlm.nih.gov/articles/PMC11526958/

January 30 (B1-065 - Pelton)Matthew Chan (Campbell Lab)

"Look, up in the lysosome! It's a transporter! It’s a GPCR! It’s…LYCHOS!"

Reading: https://www.nature.com/articles/s41594-024-01474-5

February 20 (B1-072/074)Ulysses Foote-McNabb (Strong Lab)

"Improving Anti-Venom (Never tell me the odds)"

Reading: Vázquez Torres, S., Benard Valle, M., Mackessy, S.P. et al. De novo designed proteins neutralize lethal snake venom toxins. Nature (2025). DOI

February 27 (Sze Conference Room; D1-080/084)Clint Spiegel (Visiting Scientist; Western Washington Univ.)

"Structural biology of Factor VIII complexes: characterizing inhbitor epitopes in haemophila A treatment"

(Or: "Grad school: you can check out, but you can never leave")

March 13 (B1-072/074)Jeremy Hollis (Campbell Lab)

 

 

April 3 (B1-072/074)Rachel Cueny (Lapointe Lab)

 

 

April 24 (B1-072/074)Thamiya Vasanthakumar (Campbell Group)

 

 

May 15 (B1-072/074)Shantanu Shukla (Pancera Lab)

 

 

June 5 (B1-072/074)Andrés Fernández (Campbell/Subramaniam Lab)

 

 

June 26 (M1-A305/A307)Morgan Esler (Stoddard Lab)