Journal Club
2024-2025 FHCRC Structural Biology and Molecular Biophysics Journal Club
Fred Hutch's Structural Biology and Molecular Biophysics Journal Club is held 10:30 am - 11:30 am on Thursdays in B1-072/074 unless otherwise noted on the dates below.
| Date | Presenter | Topic / Manuscript |
|---|---|---|
| October 3 (D1-080/084 - Sze) | Barry Stoddard | Kojima, KK and Kobayashi, I. (2023) “Base-excision restriction enzymes: expanding the world of epigenetic immune systems” DNA research 30: 1 - 15. DOI |
| October 24 (M4-A805/A817) | Adam Nguyen (Campbell Lab) | "cryoEM Structures of tyrosine kinase receptors" Reading: Huang et al. and Kuriyan, J. (2021) "A molecular mechanism for the generation of ligand-dependent differential outputs by the epidermal growth factor receptor" eLife (https://doi.org/10.7554/eLife.73218) |
| November 14 (D1-080/084 - Sze) | Peter Rupert (Strong Lab) | “Ferritin-scFv: A potential method for mapping of epitopes” Reading: Knovich et al. (2009) "Ferritin for the Clinician" Blood Reviews 23: 95 -104. https://www.sciencedirect.com/science/article/pii/S0268960X08000660 |
| December 19 (S1-141/142 - Steamplant) | Juliana Young (Stoddard Lab) | “The mobilization, divergence, degradation, and reconstruction of modern-day and ancestral homing endonucleases” |
| January 9 (B1-072/074) | Derin Kara (Pancera Lab) | "Computational design of prefusion-stabilized Herpesvirus gB trimers” |
| January 30 (B1-065 - Pelton) | Matthew Chan (Campbell Lab) | "Look, up in the lysosome! It's a transporter! It’s a GPCR! It’s…LYCHOS!" |
| February 20 (B1-072/074) | Ulysses Foote-McNabb (Strong Lab) | "Improving Anti-Venom (Never tell me the odds)" Reading: Vázquez Torres, S., Benard Valle, M., Mackessy, S.P. et al. De novo designed proteins neutralize lethal snake venom toxins. Nature (2025). DOI |
| February 27 (Sze Conference Room; D1-080/084) | Clint Spiegel (Visiting Scientist; Western Washington Univ.) | "Structural biology of Factor VIII complexes: characterizing inhbitor epitopes in haemophila A treatment" (Or: "Grad school: you can check out, but you can never leave") |
| March 13 (B1-072/074) | Jeremy Hollis (Campbell Lab) | "cryoET as a structural window into the cell." Reading: Rodrigues-Oliveira, T., Wollweber, F., Ponce-Toledo, R.I. et al. Actin cytoskeleton and complex cell architecture in an Asgard archaeon. Nature 613, 332–339 (2023). DOI Young LN, Villa E. Bringing Structure to Cell Biology with Cryo-Electron Tomography. Annu Rev Biophys. 2023 May 9;52:573-595. doi: 10.1146/annurev-biophys-111622-091327. PMID: 37159298; PMCID: PMC10763975. Nogales E, Mahamid J. Bridging structural and cell biology with cryo-electron microscopy. Nature. 2024 Apr;628(8006):47-56. doi: 10.1038/s41586-024-07198-2. Epub 2024 Apr 3. PMID: 38570716; PMCID: PMC11211576. |
| April 3 (B1-072/074) | Rachel Cueny (Lapointe Lab) | "Deconvoluting disparate roles of DDX6 in translational control" Reading: Coller J, Parker R. General translational repression by activators of mRNA decapping. Cell. 2005 Sep 23;122(6):875-86. doi: 10.1016/j.cell.2005.07.012. PMID: 16179257; PMCID: PMC1853273. |
| April 24 (B1-072/074) | Thamiya Vasanthakumar (Campbell Group) | "Cryo-electron tomography reveals how COPII assembles on cargo-containing membranes” Reading: Pyle, E., Miller, E.A. & Zanetti, G. Cryo-electron tomography reveals how COPII assembles on cargo-containing membranes. Nat Struct Mol Biol 32, 513–519 (2025). DOI |
| May 15 (B1-072/074) | Shantanu Shukla (Pancera Lab) |
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| June 5 (B1-072/074) | Andrés Fernández (Campbell/Subramaniam Lab) |
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| June 26 (M1-A305/A307) | Morgan Esler (Stoddard Lab) |
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