Natural and Engineered Gene Targeting Proteins

Studies of the structure, function, mechanism and engineering of homing endonucleases, rare-cutting endonucleases and gene targeting proteins.

Protein and Enzyme Engineering

Combining the use of computational algorithms with biophysical characterization to engineer proteins and enzyme catalysts for new, improved or altered biophysical properties.

DNA Restriction and Modification Enzymes

Study of the structure and mechanism of restriction endonucleases, particularly the relationship that connects restrictions endonucleases and mobile homing endonucleases.

Structural Enzymology

Short-term collaborations with biochemists and enzymologists that allow trainees to learn basic methods for structural analysis.